Analytical Data
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基因名
PODXL
- Application
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别名
PODXL；PCLP；PCLP1；Podocalyxin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00592
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表达区间
32-458aa
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氨基酸序列
QNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRF
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分子量
46.2kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PODXL (Podocalyxin-like protein) is a member of the CD34 family of sialomucins and plays crucial roles in various biological processes, including cell adhesion, migration, and signaling. Initially identified in renal podocytes, PODXL has also been implicated in cancer biology, specifically in tumor progression and metastasis. Its expression is upregulated in several malignancies, making it a potential biomarker for poor prognosis and a target for therapeutic interventions. Research into the recombinant expression of PODXL aims to elucidate its functional mechanisms, particularly in how it modulates cellular interactions within the tumor microenvironment. By producing PODXL in a recombinant system, scientists can study its structural properties, glycosylation patterns, and interactions with other proteins, paving the way for the development of diagnostic tools and novel therapeutic strategies. Understanding PODXL's role in both physiological and pathophysiological contexts is vital for advancing cancer research and improving treatment options for patients.
