Analytical Data
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基因名
HMGCLL1
- Application
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别名
HMGCLL1; 3-hydroxy-3-methylglutaryl-CoA lyase; cytoplasmic; EC 4.1.3.4; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase; er-cHL
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TB92
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表达区间
1-340aa
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氨基酸序列
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
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分子量
63.14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase-like 1) is a protein that has gained attention in the field of molecular biology due to its potential roles in various metabolic pathways and its involvement in cellular processes. This protein is a member of the HMG-CoA lyase family, which is crucial in the metabolism of ketone bodies and cholesterol synthesis. Research has shown that HMGCLL1 participates in the regulation of cellular energy metabolism and may impact conditions related to metabolic disorders, neurodegenerative diseases, and cancer. Its expression levels and functional implications suggest that HMGCLL1 could serve as a significant biomarker or therapeutic target in these diseases. Recent advances in recombinant protein expression techniques have enabled researchers to produce HMGCLL1 in significant quantities, facilitating detailed studies of its biochemical properties and interactions. Investigating the structure-function relationship of HMGCLL1 through site-directed mutagenesis and structural biology approaches has provided insights into its mechanism of action and regulatory roles. Understanding the functional dynamics of HMGCLL1 may lead to novel therapeutic strategies and enhance our knowledge of metabolic regulation, thereby opening new avenues for research in metabolic health and disease management.
