Analytical Data
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基因名
HERC1
- Application
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别名
HERC1；Probable E3 ubiquitin-Protein ligase HERC1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15751
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表达区间
3975-4360aa
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氨基酸序列
GMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA
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分子量
48.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HERC1, a member of the HECT-type ubiquitin ligase family, plays a critical role in various cellular processes, including protein degradation, signal transduction, and cellular response to stress. Research on HERC1 has gained momentum due to its involvement in key regulatory pathways linked to cancer, neurodegenerative diseases, and immune responses. The protein is known to interact with multiple substrates, influencing their stability and function through ubiquitination. Additionally, mutations and dysregulation of HERC1 have been associated with various pathologies, highlighting its potential as a therapeutic target. Recent studies have focused on characterizing HERC1's structure and enzymatic activity, as well as elucidating its molecular mechanisms. Advances in recombinant protein technology have facilitated the production of HERC1, enabling detailed investigations into its function and interactions. Understanding HERC1 at the molecular level could pave the way for novel therapeutic strategies, making it an important focus within the field of protein research.
