Analytical Data
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基因名
GMPR
- Application
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别名
GMFB;Glia maturation factor beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36959
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表达区间
1-345aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVIERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GMPR (Guanosine Monophosphate Reductase) is an essential enzyme involved in the purine nucleotide metabolism pathway, specifically converting GMP to IMP (inosine monophosphate). This enzymatic function is crucial for maintaining cellular nucleotide pools and regulating various biological processes, including DNA and RNA synthesis, cell signaling, and energy metabolism. Research has gained momentum around GMPR due to its potential implications in various diseases, particularly in cancer and metabolic disorders. The recombinant production of GMPR has emerged as a vital tool for studying its enzymatic properties, structure-function relationships, and interactions with other cellular components. Advances in recombinant DNA technology have enabled the expression of GMPR in various hosts, facilitating the purification and characterization of the enzyme for detailed biochemical studies. Furthermore, understanding GMPR's role may unveil novel therapeutic targets, as dysregulation of purine metabolism is often associated with tumor growth and resistance to treatment. Therefore, ongoing studies aim to elucidate the mechanisms governing GMPR activity and its regulatory pathways, providing insights that could inform the development of pharmacological agents aimed at modulating its function in pathological conditions.
