Analytical Data
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Gene name
GMPR
- Application
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Alternative Names
GMFB;Glia maturation factor beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36959
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Expression Region
1-345aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVIERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GMPR (Guanosine Monophosphate Reductase) is an essential enzyme involved in the purine nucleotide metabolism pathway, specifically converting GMP to IMP (inosine monophosphate). This enzymatic function is crucial for maintaining cellular nucleotide pools and regulating various biological processes, including DNA and RNA synthesis, cell signaling, and energy metabolism. Research has gained momentum around GMPR due to its potential implications in various diseases, particularly in cancer and metabolic disorders. The recombinant production of GMPR has emerged as a vital tool for studying its enzymatic properties, structure-function relationships, and interactions with other cellular components. Advances in recombinant DNA technology have enabled the expression of GMPR in various hosts, facilitating the purification and characterization of the enzyme for detailed biochemical studies. Furthermore, understanding GMPR's role may unveil novel therapeutic targets, as dysregulation of purine metabolism is often associated with tumor growth and resistance to treatment. Therefore, ongoing studies aim to elucidate the mechanisms governing GMPR activity and its regulatory pathways, providing insights that could inform the development of pharmacological agents aimed at modulating its function in pathological conditions.
