Analytical Data
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基因名
MTOR
- Application
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别名
MTOR；FRAP；FRAP1；FRAP2；Serine/threonine-Protein kinase mTOR
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42345
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表达区间
1521-1620aa
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氨基酸序列
WGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDL LDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The mechanistic target of rapamycin (mTOR) is a crucial serine/threonine kinase that functions as a central regulator of cell growth, proliferation, and survival, integrating signals from nutrients, growth factors, and cellular energy status. Its dysregulation is implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative diseases. Research on recombinant mTOR proteins has gained significant attention due to their potential applications in understanding the signaling pathways involved in these conditions and developing novel therapeutic strategies. By producing and characterizing recombinant mTOR proteins, scientists can investigate its structural properties, enzymatic activity, and interactions with various substrates and inhibitors, thereby elucidating the mechanisms by which mTOR affects cellular functions. Furthermore, these studies can contribute to the identification of mTOR-related biomarkers and aid in the design of mTOR inhibitors, which have shown promise in clinical trials as targeted therapies. Thus, investigating recombinant mTOR proteins serves not only to enhance the basic understanding of mTOR biology but also to advance the development of effective treatments for diseases associated with its dysfunction.
