Analytical Data
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基因名
CK1
- Application
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别名
CK1；C11orf57；Uncharacterized Protein NKAPD1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04264
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表达区间
2-644aa
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氨基酸序列
SRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR
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分子量
69.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK1, or Casein Kinase 1, is a serine/threonine kinase that plays a pivotal role in various cellular processes including circadian rhythm regulation, Wnt signaling, DNA repair, and cellular proliferation. Its involvement in these critical pathways underscores its significance in both normal cellular function and pathological conditions, such as cancer and neurodegenerative diseases. The study of CK1 has garnered attention due to its potential as a therapeutic target; for instance, aberrations in CK1 activity have been linked to disorders like breast cancer and schizophrenia. As research progresses, the focus has shifted towards understanding the structural and functional dynamics of CK1, particularly through recombinant protein techniques which allow for the detailed characterization of the enzyme's properties, interactions, and regulation. The recombinant expression of CK1 facilitates the exploration of its biochemical mechanisms and the development of small molecule inhibitors that could modulate its activity. This research is crucial for devising novel strategies for targeted therapies, advancing our comprehension of CK1's multifaceted roles in cell signaling networks, and revealing how alterations in CK1 function contribute to disease states. Thus, the exploration of CK1 through recombinant protein technology holds promise for both fundamental biology and clinical applications, paving the way for innovative treatments that can better address CK1-related pathologies.
