Analytical Data
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Gene name
KNSTRN
- Application
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Alternative Names
KNSTRN；C15orf23；SKAP；TRAF4AF1；Small kinetochore-associated Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y448
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Expression Region
1-316aa
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AA Sequence
MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQALKVKLEMKEERVRFLEQQTLCNNQVNDLTTALKEMEQLLEM
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Molecular Weight
39.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KNSTRN, or Kinetochore Scaffold Protein, is an essential component of the kinetochore, a protein complex that plays a crucial role in the proper segregation of chromosomes during cell division. The significance of KNSTRN lies in its function as a scaffold that organizes various protein interactions and ensures the stable attachment of microtubules to kinetochores. This is vital for maintaining genomic stability, as any dysfunction in kinetochore assembly or operation can lead to aneuploidy, a condition often associated with various cancers and developmental disorders. Research on KNSTRN has gained momentum due to its potential implications in cell biology and medicine. Recent studies have focused on elucidating the molecular mechanisms by which KNSTRN interacts with other kinetochore proteins and regulates their functions. Furthermore, understanding the structural dynamics of KNSTRN could inform therapeutic strategies aimed at targeting cellular division processes in cancer treatments. The exploration of KNSTRN's role in the kinetochore not only enhances our comprehension of cell cycle regulation but also opens new avenues for the development of innovative biotechnological applications and interventions in diseases linked to chromosome missegregation.
