Cat: PA2000-55DB

Recombinant Human IL23a Protein,His

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Analytical Data

  • Gene name

    IL23a

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    IL23a;SGRF;Interleukin-23 subunit alpha

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9NPF7

  • Expression Region

    23-328aa

  • AA Sequence

    IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCSGSTS GSGKPGSGEG STKGRAVPGG SSPAWTQCQQ LSQKLCTLAW SAHPLVGHMD LREEGDEETT NDVPHIQCGD GCDPQGLRDN SQFCLQRIHQ GLIFYEKLLG SDIFTGEPSL LPDSPVGQLH ASLLGLSQLL QPEGHHWETQ QIPSLSPSQP WQRLLLRFKI LRSLQAFVAV AARVFAHGAA TLSP

  • Molecular Weight

    70 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

IL-23A, a subunit of the interleukin-23 (IL-23) cytokine, plays a crucial role in regulating immune responses, particularly in chronic inflammatory diseases and autoimmune conditions. Its importance in Th17 cell differentiation has made it a focal point in research related to conditions such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis. Understanding the structure and function of recombinant IL-23A protein is pivotal for developing therapeutic strategies targeted at modulating immune responses. The advancement of recombinant DNA technology has enabled the production of IL-23A in sufficient quantities for both preclinical and clinical studies. Researchers aim to elucidate its mechanisms of action, potential biomarkers for disease progression, and its role in the pathogenesis of inflammatory disorders. Furthermore, recombinant IL-23A is instrumental for studying receptor interaction and signaling pathways, contributing to the development of biologics that inhibit its action and mitigate disease symptoms. Overall, the exploration of IL-23A serves to enhance our understanding of immune dysregulation and to inform novel therapeutic approaches for treating complex inflammatory conditions.

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