Analytical Data
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基因名
HNRPA2B1
- Application
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别名
HNRPA2B1；HNRPA2B1；Heterogeneous nuclear ribonucleoProteins A2/B1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22626
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表达区间
1-353aa
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氨基酸序列
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
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分子量
37.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRPA2B1, a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a crucial role in various cellular processes, including mRNA processing, splicing, and transport. The protein's functions are associated with the regulation of gene expression and RNA metabolism, making it an important subject of study in understanding cellular mechanisms and disease pathogenesis. Recent research has highlighted HNRPA2B1's involvement in neurodegenerative diseases, such as Alzheimer's and amyotrophic lateral sclerosis (ALS), where its misregulation or aggregation correlates with disease progression. Moreover, HNRPA2B1 has been implicated in the modulation of stress responses and the cellular response to DNA damage. The production and characterization of recombinant HNRPA2B1 protein facilitate the exploration of its structural and functional properties in vitro, allowing researchers to dissect its interactions with RNA and other proteins. This understanding is pivotal for elucidating its roles in RNA metabolism and its potential as a therapeutic target. By generating recombinant HNRPA2B1, studies can provide insights into how alterations in its function contribute to disease mechanisms, paving the way for future therapeutic strategies aimed at modulating hnRNP activity in neurodegenerative and other diseases.
