Analytical Data
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基因名
HIST1H2AI
- Application
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别名
HIST1H2AH; HIST1H2AI; Histone H2A type 1-H; Histone H2A/s
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96KK5
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表达区间
1-130aa
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氨基酸序列
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
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分子量
14.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AI is a critical member of the histone H2A family, primarily involved in the packaging and regulation of DNA in eukaryotic cells. Histone proteins play a fundamental role in chromatin structure and gene expression, influencing various cellular processes, including cell division, DNA repair, and gene activation. Research on HIST1H2AI specifically focuses on its role in epigenetic regulation, which is essential for understanding numerous biological mechanisms and disease pathways, such as cancer. The recombinant expression of HIST1H2AI allows researchers to study its structure, function, and interactions with other molecular players within the chromatin environment. Furthermore, recombinant HIST1H2AI provides a valuable tool for investigating the effects of post-translational modifications on histone dynamics and their subsequent impact on gene regulation. By elucidating the functional roles of HIST1H2AI, scientists aim to uncover its contributions to chromatin remodeling and cellular signaling pathways, ultimately seeking to identify potential therapeutic targets for diseases associated with chromatin dysregulation. In summary, the study of HIST1H2AI recombinant proteins not only enhances our comprehension of histone biology but also opens new avenues for therapeutic interventions in the context of epigenetic diseases.
