Analytical Data
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基因名
RPGR
- Application
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别名
RPGR；RP3；XLRP3；X-linked retinitis pigmentosa GTPase regulator
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92834
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表达区间
54-367aa
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氨基酸序列
NKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAP
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分子量
62.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPGR (Retinitis Pigmentosa GTPase Regulator) is a gene essential for the normal functioning of photoreceptors in the retina. Mutations in RPGR are the leading cause of X-linked retinitis pigmentosa (XLRP), a hereditary eye disease that leads to progressive vision loss. Research on RPGR recombinant proteins is crucial for understanding the molecular mechanisms underlying this condition. Given RPGR's role in ciliary function and photoreceptor maintenance, scientists are exploring the structure and functional domains of the RPGR protein to elucidate its interactions with other cellular components. The focus on recombinant RPGR proteins enables researchers to produce and purify functional versions of the protein, facilitating studies on its biochemical properties and cellular pathways. These studies are pivotal for the development of potential therapeutic strategies, including gene therapy and small molecule interventions, aimed at restoring photoreceptor function and preserving vision in affected individuals. Progress in this area could lead to groundbreaking treatments for XLRP and related retinal degenerative diseases, ultimately improving the quality of life for patients suffering from these conditions.
