Analytical Data
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Gene name
Clec4g
- Application
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Alternative Names
Clec4g；C-type lectin domain family 4 member G
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UXB4
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Expression Region
55-293aa
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AA Sequence
KASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC
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Molecular Weight
52.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Clec4g, also known as C-type lectin domain family 4 member G, is a protein that plays a significant role in the immune system, particularly in the recognition and clearance of pathogens. It is primarily expressed in dendritic cells and macrophages, where it functions as a pattern recognition receptor (PRR) that can bind to specific carbohydrate structures on the surface of pathogens, thereby facilitating their uptake and subsequent immune response. Research into Clec4g has gained traction due to its potential implications in vaccine development, immunotherapy, and understanding host-pathogen interactions. Recent studies have demonstrated its involvement in various infectious diseases, including viral infections such as HIV and influenza, as well as in tumors, where it may influence the efficacy of immune responses. The recombinant expression of Clec4g allows for detailed functional studies and potential therapeutic applications, including the development of targeted immunotherapies and the enhancement of vaccine responses. Understanding the molecular mechanisms of Clec4g could lead to innovative strategies for improving immune system functionality and combating a range of diseases.
