Analytical Data
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基因名
GFRA3
- Application
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别名
GFRA3TRNR1;GDNF family receptor alpha-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60609
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表达区间
32-374aa
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氨基酸序列
DPLPTESRL MNSCLQARRK CQADPTCSAA YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG CMCHRRMKNQ VACLDIYWTV HRARSLGNYE LDVSPYEDTV TSKPWKMNLS KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK AYGEACSGPH CQRHVCLRQL LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA LPPVAPNCLE LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR FHSQLFSQDW PHPTFAVMAH QNEN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GFRA3 (GFR alpha 3) is a member of the glial cell line-derived neurotrophic factor (GDNF) family receptor alpha (GFRA) subfamily, which plays a crucial role in neurodevelopment and the maintenance of neuronal function. The GFRA3 protein is primarily known for its involvement in modulating the signaling pathways of GDNF and related neurotrophic factors, making it essential for the survival and differentiation of certain types of neurons, particularly in the peripheral nervous system. Abnormal expression or dysfunction of GFRA3 has been linked to various neurodegenerative diseases and developmental disorders, highlighting its potential as a therapeutic target. Recent studies have focused on the characterization of GFRA3 recombinant proteins to better understand its functional implications in neuronal signaling and its interactions with ligand molecules. Development of GFRA3 recombinant proteins allows for in-depth exploration of receptor activation mechanisms and downstream signaling pathways, facilitating investigation into the role of GFRA3 in neural repair and regeneration. Additionally, understanding the structure and function of GFRA3 can pave the way for the design of novel therapeutic strategies aimed at mitigating neurological diseases associated with GFRA3 dysregulation. Therefore, research into GFRA3 recombinant proteins not only enhances our knowledge of neurobiological processes but also holds promise for innovative treatments in neurodegenerative conditions.
