Analytical Data
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基因名
Gfra1
- Application
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别名
Gfra1；GDNFRA；RETL1;GDNF family receptor alpha-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56159
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表达区间
25-429aa
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氨基酸序列
DRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF SLASGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRVVPFISD VFQQVEHIPK GNNCLDAAKA CNLDDICKKY RSAYITPCTT SVSNDVCNRR KCHKALRQFF DKVPAKHSYG MLFCSCRDIA CTERRRQTIV PVCSYEEREK PNCLNLQDSC KTNYICRSRL ADFFTNCQPE SRSVSSCLKE NYADCLLAYS GLIGTVMTPN YIDSSSLSVA PWCDCSNSGN DLEECLKFLN FFKDNTCLKN AIQAFGNGSD VTVWQPAFPV QTTTATTTTA LRVKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGN THLCISNGNY EKEGLGASS
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分子量
46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gfra1 (GDNF family receptor alpha 1) is a crucial component of the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, playing a significant role in neuronal survival, differentiation, and development. This receptor is primarily expressed in the nervous system and is essential for the maintenance of dopaminergic neurons in the midbrain, making it a focal point for research related to neurodegenerative diseases such as Parkinson's disease. The study of Gfra1 recombinant protein is vital for understanding its structure-function relationships, signaling mechanisms, and interactions with GDNF and other co-receptors. Enhanced insights into Gfra1 can lead to novel therapeutic strategies aimed at neuroprotection and regeneration of damaged neuronal tissues. The production of Gfra1 as a recombinant protein in various expression systems allows researchers to investigate its biochemical properties, assess its functional implications in neural development, and explore its potential in treatment modalities for neurodegenerative disorders. Furthermore, characterizing Gfra1 can aid in unraveling its mechanistic roles in cell signaling pathways and its impact on neuroplasticity. Therefore, the ongoing study of Gfra1 recombinant protein encompasses diverse biomedical applications, particularly in the realms of neurobiology, cell signaling, and regenerative medicine.
