Analytical Data
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Gene name
Gfra1
- Application
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Alternative Names
Gfra1；GDNFRA；RETL1;GDNF family receptor alpha-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56159
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Expression Region
25-429aa
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AA Sequence
DRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF SLASGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRVVPFISD VFQQVEHIPK GNNCLDAAKA CNLDDICKKY RSAYITPCTT SVSNDVCNRR KCHKALRQFF DKVPAKHSYG MLFCSCRDIA CTERRRQTIV PVCSYEEREK PNCLNLQDSC KTNYICRSRL ADFFTNCQPE SRSVSSCLKE NYADCLLAYS GLIGTVMTPN YIDSSSLSVA PWCDCSNSGN DLEECLKFLN FFKDNTCLKN AIQAFGNGSD VTVWQPAFPV QTTTATTTTA LRVKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGN THLCISNGNY EKEGLGASS
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Molecular Weight
46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gfra1 (GDNF family receptor alpha 1) is a crucial component of the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, playing a significant role in neuronal survival, differentiation, and development. This receptor is primarily expressed in the nervous system and is essential for the maintenance of dopaminergic neurons in the midbrain, making it a focal point for research related to neurodegenerative diseases such as Parkinson's disease. The study of Gfra1 recombinant protein is vital for understanding its structure-function relationships, signaling mechanisms, and interactions with GDNF and other co-receptors. Enhanced insights into Gfra1 can lead to novel therapeutic strategies aimed at neuroprotection and regeneration of damaged neuronal tissues. The production of Gfra1 as a recombinant protein in various expression systems allows researchers to investigate its biochemical properties, assess its functional implications in neural development, and explore its potential in treatment modalities for neurodegenerative disorders. Furthermore, characterizing Gfra1 can aid in unraveling its mechanistic roles in cell signaling pathways and its impact on neuroplasticity. Therefore, the ongoing study of Gfra1 recombinant protein encompasses diverse biomedical applications, particularly in the realms of neurobiology, cell signaling, and regenerative medicine.
