Analytical Data
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基因名
CDC20
- Application
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别名
CDC20；Cell division cycle Protein 20 homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12834
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表达区间
1-499aa
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氨基酸序列
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSH SAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQ PENSQTPTKKEHQKAWVLNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKV LYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV QLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT MSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR
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分子量
81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDC20 (cell division cycle 20) is a critical regulatory protein that plays a vital role in the progression of the cell cycle, particularly during the metaphase-to-anaphase transition in mitosis. As an essential co-activator of the anaphase-promoting complex/cyclosome (APC/C), CDC20 facilitates the ubiquitination and subsequent degradation of specific target proteins that regulate the cell cycle. Dysregulation of CDC20 has been implicated in various cancers, making it a significant focus of research. Scientists aim to understand its structural characteristics, functional mechanisms, and interactions with other proteins to elucidate its role in tumorigenesis and cell cycle regulation. Additionally, CDC20 has attracted attention as a potential therapeutic target; strategies aimed at inhibiting its activity could pave the way for novel cancer treatments. Studies involving recombinant CDC20 protein have led to insights into its molecular interactions, conformational changes, and regulatory pathways, providing a foundation for designing drugs that could selectively disrupt its function in cancer cells.
