Analytical Data
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基因名
HEATR2
- Application
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别名
BC053401; C76907; FLJ20397; FLJ25564; FLJ31671; FLJ39381; HEAT repeat containing protein 2; HEAT repeat-containing protein 2; HEAT2_HUMAN; HEATR2; hypothetical protein FLJ20397; MGC125214; MGC60818
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86Y56
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表达区间
1-223aa
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氨基酸序列
MRLKLFSILSTVLLRATDTINSQGQFPSYLETVTKDILAPNLQWHAGRTAAAIRTAAVSCLWALTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRLISCRIINTFLKTSGGMTDPEKLIKIYPELLKRLDDVSNDVRMAAASTLVTWLQCVKGANAKSYYQSSVQYLYRELLVHLDDPERAIQDAILDVPGSPSPSAMIGSFLRPPHPWRTVSQLNLFSS
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分子量
51.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HEATR2, or HEAT repeat containing 2, is a protein that has garnered attention in recent years due to its potential involvement in various cellular processes and disease mechanisms. It is characterized by a series of HEAT repeats, which are structural motifs that facilitate protein–protein interactions. Initial studies suggest that HEATR2 plays a critical role in the maintenance of genome integrity, particularly during DNA repair and replication. Its essentiality has been highlighted in several model organisms, where knockdown or mutation leads to increased sensitivity to genotoxic stress. Furthermore, aberrations in HEATR2 have been implicated in several diseases, including cancer, where altered expression levels correlate with tumor progression. Recent advances in proteomics and molecular biology techniques have enabled researchers to investigate the functional dynamics of HEATR2, revealing its potential interactions with key regulatory proteins involved in DNA damage response and repair pathways. Understanding the precise mechanisms through which HEATR2 operates could not only deepen our knowledge of fundamental biological processes but also pave the way for novel therapeutic strategies in cancer and other diseases. As researchers continue to unravel the complexities of HEATR2's role in cellular functions, it remains a promising target for further exploration in the fields of molecular biology and medicine.
