Analytical Data
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Gene name
FBP1
- Application
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Alternative Names
FBP1；C1orf39；TOCA1;Formin-binding Protein 1-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09467
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Expression Region
1-338aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
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Molecular Weight
39 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBP1, or Fructose-1,6-bisphosphatase 1, is a key enzyme in gluconeogenesis, the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. Its regulation is critical in maintaining glucose homeostasis, particularly during fasting or intense exercise when glucose levels may drop. Dysregulation of FBP1 has been linked to metabolic disorders such as diabetes, making it a valuable target for therapeutic research. The recombinant production of FBP1 protein allows for detailed biochemical characterization and functional studies, enabling scientists to investigate its structure, enzymatic activity, and regulation mechanisms. Through techniques such as site-directed mutagenesis and structural analysis, researchers can derive insights into FBP1’s role in metabolic pathways and its interactions with other cellular components. Understanding the nuances of FBP1's function may reveal vital information about its potential as a drug target for managing metabolic diseases. Furthermore, recombinant FBP1 can be used in industrial applications, such as biofuel production, where enhancing glucose availability is vital. Overall, FBP1 recombinant protein research not only furthers our understanding of metabolic regulation but also opens new avenues for therapeutic and industrial advancements.
