Analytical Data
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Gene name
FKBP4
- Application
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Alternative Names
FKBP4；FKBP52;Peptidyl-prolyl cis-trans isomerase FKBP4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q02790
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Expression Region
1-459aa
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AA Sequence
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIG DRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVG EVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGI IRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDL PYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLK SFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDS NNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRI RRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAG SQSQVETEALEHHHHHH
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Molecular Weight
53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FKBP4, or FK506-binding protein 4, is a member of the immunophilin family, which plays a crucial role in various cellular processes, including protein folding, trafficking, and the regulation of intracellular signaling pathways. Its significance is highlighted in studies of stress response, immune function, and various diseases, including cancer and neurodegenerative disorders. As a co-chaperone of heat shock proteins, FKBP4 facilitates the maturation and stabilization of client proteins, thereby influencing cellular homeostasis and survival. Research into FKBP4 has gained momentum due to its potential as a therapeutic target; mutations or dysregulation of FKBP4 are associated with several pathologies, making it a candidate for drug development. Moreover, FKBP4 is involved in the modulation of steroid receptor activity, further elucidating its role in hormone signaling and endocrine regulation. The recombination and expression of FKBP4 as a protein offer valuable insights into its structure-function relationships and interactions with other molecular partners. This understanding is essential for developing strategies to modulate its function in disease contexts, emphasizing its relevance in current biomedical research and therapeutic innovations. As such, the study of FKBP4 and its recombinant forms is critical for unveiling its biological roles and potential implications in targeted therapies.
