Analytical Data
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基因名
GPRASP2
- Application
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别名
GPRASP2; G-protein coupled receptor-associated sorting protein 2; GASP-2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96D09
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表达区间
1-838aa
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氨基酸序列
MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS
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分子量
120.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPRASP2, or G protein-coupled receptor associated sorting protein 2, is a member of the GPRASP family that plays a significant role in the trafficking and sorting of G protein-coupled receptors (GPCRs) within cells. GPCRs are crucial for many physiological processes, including sensory perception, immune responses, and neurotransmission, making them important targets for drug discovery. Dysregulation of GPCR signaling is implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Understanding GPRASP2 is essential, as it influences the expression and function of GPCRs on the cell surface, thereby impacting cellular signaling pathways. Research into GPRASP2 involves the characterization of its structure, function, and interactions with GPCRs and other cellular partners. Additionally, studies have shown that GPRASP2 can affect the internalization and recycling of receptors, further elucidating its role in receptor regulation. The investigation of GPRASP2 and its mechanisms may provide insights into therapeutic strategies for conditions associated with GPCR misregulation, making it a pertinent focus in both cellular biology and pharmacology. As the understanding of GPRASP2 continues to evolve, it reinforces the significance of post-translational modifications and cellular sorting processes in maintaining GPCR homeostasis. This underscores the necessity for developing GPRASP2 as a potential biomarker or therapeutic target, paving the way for innovative treatment options in various diseases where GPCRs play a critical role. Overall, the study of GPRASP2 as a recombinant protein aids in comprehensively understanding its biological functions and therapeutic implications in human health.
