Analytical Data
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Gene name
GPRASP2
- Application
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Alternative Names
GPRASP2; G-protein coupled receptor-associated sorting protein 2; GASP-2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96D09
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Expression Region
1-838aa
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AA Sequence
MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS
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Molecular Weight
120.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPRASP2, or G protein-coupled receptor associated sorting protein 2, is a member of the GPRASP family that plays a significant role in the trafficking and sorting of G protein-coupled receptors (GPCRs) within cells. GPCRs are crucial for many physiological processes, including sensory perception, immune responses, and neurotransmission, making them important targets for drug discovery. Dysregulation of GPCR signaling is implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Understanding GPRASP2 is essential, as it influences the expression and function of GPCRs on the cell surface, thereby impacting cellular signaling pathways. Research into GPRASP2 involves the characterization of its structure, function, and interactions with GPCRs and other cellular partners. Additionally, studies have shown that GPRASP2 can affect the internalization and recycling of receptors, further elucidating its role in receptor regulation. The investigation of GPRASP2 and its mechanisms may provide insights into therapeutic strategies for conditions associated with GPCR misregulation, making it a pertinent focus in both cellular biology and pharmacology. As the understanding of GPRASP2 continues to evolve, it reinforces the significance of post-translational modifications and cellular sorting processes in maintaining GPCR homeostasis. This underscores the necessity for developing GPRASP2 as a potential biomarker or therapeutic target, paving the way for innovative treatment options in various diseases where GPCRs play a critical role. Overall, the study of GPRASP2 as a recombinant protein aids in comprehensively understanding its biological functions and therapeutic implications in human health.
