Analytical Data
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基因名
FPR1
- Application
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别名
FPR1；fMet-Leu-Phe receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21462
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表达区间
1-350aa
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氨基酸序列
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
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分子量
44.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FPR1, or Formyl Peptide Receptor 1, is a G protein-coupled receptor that plays a crucial role in the immune response, particularly in mediating the effects of formylated peptides which are often released by bacteria and damaged tissues. Research on FPR1 has gained prominence due to its involvement in various physiological processes such as chemotaxis, phagocytosis, and the inflammatory response. The receptor is not only important in innate immunity but has also been implicated in a range of pathological conditions, including autoimmune diseases, cancer progression, and chronic inflammatory disorders. Given its significant role in mediating immune responses, FPR1 is considered a potential therapeutic target. The study of FPR1 recombinant proteins is particularly relevant as it enables scientists to explore the structural and functional properties of this receptor in detail. By producing FPR1 in a recombinant system, researchers can investigate its binding interactions with ligands, signaling pathways, and regulatory mechanisms, further elucidating how it can be manipulated for therapeutic purposes. Advancements in this area could lead to novel strategies for modulating immune responses in various diseases, thereby offering new avenues for treatment and improving patient outcomes. Overall, the study of FPR1 and its recombinant proteins represents a vital intersection of immunology and therapeutic development, holding promise for innovations in managing immune-related disorders.
