Analytical Data
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基因名
FADD
- Application
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别名
FADD；MORT1;FAS-associated death domain Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13158
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表达区间
1-208aa
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氨基酸序列
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
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分子量
30.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FADD (Fas-associated protein with death domain) is a critical adaptor protein that plays a vital role in the apoptosis signaling pathway, primarily mediated by the Fas receptor. Its function is crucial in various physiological processes, including immune responses, cell proliferation, and homeostasis. The dysregulation of FADD-mediated signaling pathways has been implicated in numerous diseases, such as cancer, autoimmune disorders, and neurodegenerative conditions. Research on recombinant FADD protein is essential for understanding its structural and functional properties, providing insights into its interactions with other proteins involved in apoptotic signaling. Additionally, studying FADD in a recombinant form allows for the exploration of its role in various biophysical and biochemical assays, contributing to the development of therapeutic strategies. By expressing and purifying recombinant FADD, researchers aim to elucidate its mechanism of action and identify potential small-molecule inhibitors that could modulate its function in disease contexts. The ongoing research on recombinant FADD protein holds promise for advancing our understanding of programmed cell death and its implications for human health.
