Analytical Data
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Gene name
NPR1
- Application
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Alternative Names
NPR1；ANPRA；Atrial natriuretic peptide receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16066
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Expression Region
33-473aa
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AA Sequence
GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE
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Molecular Weight
49.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPR1 (NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1) is a critical regulator of plant immunity, playing a pivotal role in the signaling pathways that trigger defense responses against pathogens. Discovered in Arabidopsis thaliana, NPR1 is essential for the activation of systemic acquired resistance (SAR), a form of plant immunity that provides broad-spectrum protection against diverse pathogens. The protein acts as a transcription co-activator, promoting the expression of pathogenesis-related (PR) genes upon pathogen attack. Research into NPR1's structure and function has revealed its dynamic behavior, including redox modification and oligomerization, which modulate its activity and localization within cells. Since its identification, much interest has focused on understanding the molecular mechanisms that govern NPR1's role in plant defense, as well as its interaction with other immune signaling components such as salicylic acid. Harnessing NPR1's function has implications for agricultural biotechnology, where enhancing plant resistance to diseases can lead to improved crop yields and sustainability. Recent advances in recombinant protein technology have enabled the production and characterization of NPR1, facilitating deeper insights into its role in immunity and potential applications in developing disease-resistant crops. The ongoing research aims not only to unravel the complexities of NPR1-mediated signaling but also to translate these findings into practical solutions for combatting plant diseases in various agricultural systems.
