Analytical Data
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基因名
CDC19
- Application
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别名
CDC19；PYK1；Pyruvate kinase
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00549
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表达区间
2-500aa
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氨基酸序列
SRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV
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分子量
56.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDC19, also known as RNA polymerase II subunit RPB1, plays a crucial role in transcription regulation by being integral to the transcription machinery in eukaryotic cells. It is a vital component of the RNA polymerase II complex that synthesizes mRNA, as well as snRNA and miRNA, thereby influencing gene expression. Research on CDC19 recombinant protein focuses on its function and regulation within the context of cell cycle progression and differentiation. Abnormalities in CDC19 activity can lead to various diseases, including cancer, making it a significant target for therapeutic interventions. The study of CDC19 recombinant proteins has advanced our understanding of the molecular mechanisms governing transcription and its implications in malignancies, offering potential avenues for drug design and development. The availability of CDC19 in recombinant form allows for detailed structural and functional studies, enabling scientists to explore its interactions with other transcription factors and regulatory proteins. Understanding these interactions is pivotal in elucidating the complex networks that regulate gene expression and cellular responses to stimuli. As research progresses, the insights gained from CDC19 studies may contribute to the development of novel strategies for targeting transcriptional dysregulation in diseases, highlighting its importance in molecular biology and pharmacology.
