Recombinant Human ATM Protein，His

ATM (Ataxia Telangiectasia Mutated) is a key protein involved in the cellular response to DNA damage, playing a critical role in maintaining genomic stability. Mutations in the ATM gene are associated with Ataxia Telangiectasia, a severe neurodegenerative disorder characterized by immunodeficiency, cancer predisposition, and progressive ataxia. ATM is a sensor of double-strand DNA breaks and initiates signaling pathways to activate DNA repair mechanisms, cell cycle checkpoints, and apoptotic processes. Recent studies have highlighted ATM's broader implications beyond DNA repair, including its involvement in metabolic regulation, oxidative stress response, and immune function. Due to its multifaceted roles, ATM has gained attention as a potential therapeutic target in cancer treatment, particularly in tumors with homologous recombination deficiency. Researchers are now focusing on the structural and functional characterization of ATM, investigating the consequences of its dysregulation in various diseases, and exploring its interactions with other cellular pathways. Understanding the precise mechanisms of ATM function may pave the way for novel approaches in gene therapy and targeted cancer treatments, offering hope for patients with ATM-related disorders and other conditions linked to DNA damage response pathways.