Analytical Data
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Gene name
ATM
- Application
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Alternative Names
ATM；Serine-Protein kinase ATM
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43313
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Expression Region
1-138aa
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AA Sequence
MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVVKATFAYISNCHK TKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSL LLKDIKSGLGGAWAFVLRDVIYTLIHYINQRKLTIFSQ
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATM (Ataxia Telangiectasia Mutated) is a key protein involved in the cellular response to DNA damage, playing a critical role in maintaining genomic stability. Mutations in the ATM gene are associated with Ataxia Telangiectasia, a severe neurodegenerative disorder characterized by immunodeficiency, cancer predisposition, and progressive ataxia. ATM is a sensor of double-strand DNA breaks and initiates signaling pathways to activate DNA repair mechanisms, cell cycle checkpoints, and apoptotic processes. Recent studies have highlighted ATM's broader implications beyond DNA repair, including its involvement in metabolic regulation, oxidative stress response, and immune function. Due to its multifaceted roles, ATM has gained attention as a potential therapeutic target in cancer treatment, particularly in tumors with homologous recombination deficiency. Researchers are now focusing on the structural and functional characterization of ATM, investigating the consequences of its dysregulation in various diseases, and exploring its interactions with other cellular pathways. Understanding the precise mechanisms of ATM function may pave the way for novel approaches in gene therapy and targeted cancer treatments, offering hope for patients with ATM-related disorders and other conditions linked to DNA damage response pathways.
