Analytical Data
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基因名
CLCA1
- Application
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别名
CLCA1；CACC1；Calcium-activated chloride channel regulator 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A8K7I4
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表达区间
677-776aa
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氨基酸序列
ALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQV CFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAP
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLCA1 (Chloride Channel Accessory 1) is a member of the CLCA protein family that is primarily involved in regulating chloride ion channels and modulating epithelial functions, particularly in respiratory and intestinal tissues. Recent studies have highlighted its role in physiological processes such as mucus secretion and ion transport, making it a critical player in maintaining epithelial homeostasis. Dysregulation of CLCA1 has been associated with various pathological conditions, including asthma, cystic fibrosis, and other respiratory diseases, prompting researchers to investigate its potential as a therapeutic target. The production of recombinant CLCA1 protein through molecular cloning techniques has enabled detailed studies of its structure and function. This has allowed for the elucidation of its interactions with other proteins and its role in signaling pathways, offering insights into its contributions to cellular processes. The characterization of CLCA1's functional properties could lead to the development of novel interventions for diseases linked to chloride channel dysfunction, thus underscoring the importance of ongoing research in this area.
