Analytical Data
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Gene name
HRH2
- Application
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Alternative Names
(H2R)(HH2R)(Gastric receptor I)
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Species
Gorilla gorilla gorilla
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q76MS7
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Expression Region
290-359aa
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Molecular Weight
15.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HRH2, also known as the human histamine receptor H2, is a key member of the histamine receptor family, which plays a vital role in various physiological processes including gastric acid secretion, neurotransmission, and immune responses. The exploration of HRH2 recombinant proteins has garnered significant interest due to its potential applications in therapeutic interventions for conditions like gastric ulcers, allergies, and even certain forms of cancer. Historically, HRH2 has been a target for the development of antihistamines and other drugs that modulate its activity. The expression and purification of HRH2 as a recombinant protein enable detailed studies of its structure and function, facilitating the identification of novel drug candidates and enhancing our understanding of its role in human health and disease. With advances in molecular biology techniques, researchers have made strides in producing HRH2 in various expression systems, allowing for high-yield production and functional characterization. These efforts are essential for developing pharmacological agents that could selectively target HRH2, potentially leading to more effective treatments with fewer side effects. Overall, the research on HRH2 recombinant proteins is pivotal for both basic science and translational medicine, paving the way for new therapeutic strategies to harness the benefits of modulating histamine signaling pathways in various pathological conditions.
