Analytical Data
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Gene name
EDAR
- Application
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Alternative Names
EDAR；DL;Tumor necrosis factor receptor superfamily member EDAR
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UNE0
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Expression Region
27-448aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSEYSNCGENEYYNQTTGLCQECPPCGPG EEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLT PGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATS GASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIV LIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKD EFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLL SLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCL EKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRIST AGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EDAR (Ectodysplasin A Receptor) is a member of the tumor necrosis factor receptor (TNFR) superfamily, primarily involved in ectodermal development, particularly in the formation of skin, hair, and teeth. Mutations in the EDAR gene have been linked to a variety of ectodermal dysplasias, leading to phenotypic variations such as changes in hair texture and dental anomalies. The study of recombinant EDAR proteins has gained prominence as researchers aim to elucidate the receptor's structure-function relationship and its signaling pathways. By generating recombinant EDAR proteins, scientists are able to mimic the natural receptor's interaction with its ligand, ectodysplasin A (EDA), and assess their role in cellular responses and developmental processes. This research is critical for understanding the molecular mechanisms underlying ectodermal development and for developing potential therapeutic strategies for ectodermal dysplasia disorders. Furthermore, by investigating how EDAR signaling can be modulated, there is the potential to discover novel approaches to enhance skin and hair regeneration, which is of great interest in the field of regenerative medicine. Overall, the research into recombinant EDAR proteins represents a significant advancement in developmental biology, offering insights that could not only improve our understanding of genetic conditions but also lay the groundwork for innovative treatment options.
