Analytical Data
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基因名
CIS3
- Application
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别名
(Covalently-linked cell wall protein 5/11)(Protein with internal repeats 4)(Soluble cell wall protein 8)
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种属
Saccharomyces cerevisiae
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P47001
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表达区间
65-227aa
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分子量
24.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CIS3 (cytokine-inducible SH2-containing protein 3) is an important signaling molecule in the immune system, functioning primarily in the regulation of cytokine signaling pathways. Researchers have recognized the significance of CIS3 in mediating responses to various cytokines, including interleukin-6 (IL-6) and interferons, which play crucial roles in immune responses and inflammation. The study of CIS3 has garnered attention due to its potential implications in various diseases, including autoimmune disorders and cancers. The expression of CIS3 can be induced by pro-inflammatory cytokines, which suggests that it acts as a feedback regulator, modulating the intensity and duration of immune responses. Moreover, CIS3 has been implicated in the process of oncogenesis, where its dysregulation may contribute to the malignant transformation of cells. Understanding the structural and functional properties of CIS3, particularly through recombinant protein techniques, has allowed researchers to elucidate its mechanisms of action and interaction with other signaling molecules. This research is vital for the development of therapeutic strategies that could target CIS3-related pathways, offering opportunities for innovative treatments in conditions characterized by abnormal cytokine signaling. Additionally, recombinant CIS3 protein can be utilized in experimental settings to further investigate its biological functions and interactions, thereby advancing the understanding of immune regulation and its associated pathologies.
