Analytical Data
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基因名
ERLIN1
- Application
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别名
ERLIN1；C10orf69；KE04；KEO4；Erlin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75477
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表达区间
1-348aa
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氨基酸序列
MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG
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分子量
42.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERLIN1, or endoplasmic reticulum-enriched gene, is an important protein that has drawn attention due to its role in various cellular processes and diseases. Initially identified as a key player in endoplasmic reticulum (ER) function, ERLIN1 is involved in the regulation of protein quality control and ER-associated degradation pathways. Research suggests that it interacts with the E3 ubiquitin ligase complex, impacting the stability and turnover of misfolded proteins. Furthermore, ERLIN1 is implicated in the regulation of lipid metabolism and the immune response, making it a point of interest in studies related to metabolic disorders and autoimmune diseases. Recent investigations have also highlighted its potential association with cancer progression and the response to therapy, underscoring its relevance in oncological research. Given these roles, the expression, activity, and potential post-translational modifications of ERLIN1 have become key areas of study, with researchers exploring its full biological impact and possible therapeutic implications. Understanding the mechanisms underlying ERLIN1's function could provide insights into the development of novel treatment strategies for various diseases, making it a significant focus in the fields of molecular biology and medicine.
