Analytical Data
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Gene name
NLRP6
- Application
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Alternative Names
(Angiotensin II/vasopressin receptor)(PYRIN-containing APAF1-like protein 5)
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Species
Human
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Source
Baculovirus
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P59044
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Expression Region
1-892aa
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Molecular Weight
101.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLRP6, a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, plays a critical role in the regulation of the immune response and inflammation. Recent studies have highlighted its involvement in various physiological processes, including the maintenance of gut homeostasis and the modulation of microbiota composition. NLRP6 is known to form inflammasomes, which are multiprotein complexes that activate caspase-1 and lead to the maturation of pro-inflammatory cytokines, such as IL-1β and IL-18. Dysregulation of NLRP6 has been linked to several pathological conditions, including inflammatory bowel disease (IBD), obesity, and colorectal cancer. Therefore, the recombinant expression of NLRP6 protein aims to elucidate its functional mechanisms and interactions within the immune signaling pathways. Characterizing the biochemical properties and functional roles of NLRP6 through recombinant techniques can provide insights into its therapeutic potential and the development of targeted strategies for diseases associated with its dysfunction. Additionally, understanding NLRP6's role in modulating the immune landscape can pave the way for novel approaches in managing inflammatory disorders and enhancing gut health. Overall, research on NLRP6 recombinant protein holds promise for advancing our knowledge of innate immunity and translating this understanding into clinical applications.
