Analytical Data
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Gene name
FOXG1
- Application
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Alternative Names
(Brain factor 1)(BF-1)(BF1)(Brain factor 2)(BF-2)(BF2)(hBF-2)(Forkhead box protein G1A)(Forkhead box protein G1B)(Forkhead box protein G1C)(Forkhead-related protein FKHL1)(HFK1)(Forkhead-related protein FKHL2)(HFK2)(Forkhead-related protein FKHL3)(HFK3)
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Species
Human
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55316
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Expression Region
1-489aa
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Molecular Weight
53.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXG1 (Forkhead box protein G1) is a crucial transcription factor that plays a significant role in brain development and function. Mutations or disruptions in the FOXG1 gene are associated with neurodevelopmental disorders, particularly autism spectrum disorders (ASD) and intellectual disabilities. Researchers are increasingly focused on studying FOXG1 due to its involvement in the regulation of neural stem cell proliferation and differentiation, as well as its role in the maturation of specific brain regions, including the forebrain. The interest in FOXG1 also stems from its potential as a therapeutic target; manipulating its activity may provide insights into novel treatments for FOXG1-related syndromes and broader neurodevelopmental conditions. In recent studies, recombinant FOXG1 proteins have been utilized to investigate the molecular mechanisms underlying its function, including DNA binding properties, interaction with other transcriptional regulators, and effects on downstream gene expression. Understanding these aspects at a molecular level is vital for deciphering the pathways affected in FOXG1-related disorders and for developing targeted interventions. Thus, the study of recombinant FOXG1 proteins is not only essential for elucidating its biological roles but also for advancing therapeutic strategies in neurodevelopmental disabilities linked to metabolic and genetic disruptions.
