Analytical Data
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基因名
DNAJC27
- Application
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别名
DNAJC27；RABJS；RBJ;DnaJ homolog subfamily C member 27
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZQ0
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表达区间
1-273aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMEANMPK RKEPGRSLRI KVISMGNAEV GKSCIIKRYC EKRFVSKYLA TIGIDYGVTK VHVRDREIKV NIFDMAGHPF FYEVRNEFYK DTQGVILVYD VGQKDSFDAL DAWLAEMKQE LGPHGNMENI IFVVCANKID CTKHRCVDES EGRLWAESKG FLYFETSAQT GEGINEMFQT FYISIVDLCE NGGKRPTTNS SASFTKEQAD AIRRIRNSKD SWDMLGVKPG ASRDEVNKAY RKLAVLLHPD KCVAPGSEDA FKAVVNARTA LLKNIK
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJC27 is a member of the DnaJ protein family, which plays a crucial role in protein folding, cellular stress responses, and the maintenance of proteostasis. This co-chaperone is known to interact with heat shock proteins (HSPs), particularly HSP70, facilitating the proper folding and maturation of client proteins. Recent studies have highlighted the importance of DNAJC27 in various physiological processes, including mitochondrial function and cellular survival under stress conditions. Dysregulation of DNAJC27 has been implicated in several diseases, such as neurodegenerative disorders and cancer, suggesting that it may serve as a biomarker or therapeutic target. Understanding the structural characteristics and functional mechanisms of DNAJC27 through recombinant protein studies can provide insights into its role in cellular homeostasis and disease progression. By producing recombinant DNAJC27, researchers aim to investigate its interactions with client proteins and HSPs, and elucidate its contribution to cellular functions. This research holds potential for developing innovative therapeutic strategies that leverage the chaperone system to treat diseases associated with protein misfolding and aggregation.
