Analytical Data
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Gene name
DLL4
- Application
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Alternative Names
DLL4;Delta-like Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR61
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Expression Region
27-524aa
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AA Sequence
SGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTF GTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPG DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICS DNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGC HEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGW GGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGS CRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC RCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP
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Molecular Weight
56 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DLL4 (Delta-like ligand 4) is a member of the Notch signaling pathway and plays a crucial role in regulating angiogenesis and lymphangiogenesis during development and in pathological conditions. It's primarily expressed in endothelial cells and is involved in the differentiation and function of various immune and stem cells. Research on DLL4 has gained momentum due to its implications in tumor biology, where it promotes the formation of a specialized vascular network that supports tumor growth and metastasis. The DLL4-Notch signaling axis has been shown to modulate tumor microenvironment interactions, influencing angiogenic sprouting and immune cell infiltration, thereby potentially serving as a therapeutic target for cancer treatment. Recombinant DLL4 protein is increasingly utilized in scientific studies to elucidate its biological functions and mechanisms of action. Specifically, researchers are investigating its potential role in enhancing or inhibiting tumor progression through targeted modulation of the Notch signaling pathway. Understanding the structure-function relationship of DLL4 through the use of recombinant forms can facilitate the development of DLL4-based therapeutics, such as monoclonal antibodies or small molecule inhibitors, aiming to control aberrant angiogenesis in various diseases, particularly cancer. Overall, DLL4 represents a significant focus of biological and pharmacological research aimed at unraveling its diverse functions in development, immunity, and pathology.
