Analytical Data
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Gene name
GLUT2
- Application
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Alternative Names
GLUT2；GLUT2；Solute carrier family 2. facilitated glucose transporter member 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11168
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Expression Region
1-524aa
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AA Sequence
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
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Molecular Weight
57.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GLUT2, or Glucose Transporter Type 2, is a member of the glucose transporter family that plays a crucial role in glucose homeostasis, predominantly in the liver, pancreas, and intestines. It facilitates the transport of glucose across cell membranes, thereby regulating blood sugar levels and influencing cellular metabolism. Research into GLUT2 has significantly advanced our understanding of glucose metabolism, particularly in relation to diabetes and other metabolic disorders. The recombinant expression of GLUT2 allows for detailed studies of its structure-function relationships, enabling insights into its transport mechanisms and regulatory pathways. Furthermore, the production of GLUT2 as a recombinant protein provides a valuable tool for investigating its interactions with various ligands and inhibitors, which can lead to the development of therapeutic strategies aimed at modulating glucose transport in disease states. As such, GLUT2 recombinant protein studies are pivotal for advancing knowledge in metabolic regulation and for exploring potential pharmacological applications in the treatment of conditions like Type 2 diabetes and obesity. The emphasis on creating functional recombinant GLUT2 protein in heterologous systems highlights the importance of protein folding, post-translational modifications, and membrane localization, which are critical for its activity and relevance in biological systems.
