Analytical Data
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基因名
P2RX7
- Application
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别名
P2RX7；P2X purinoceptor 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99572
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表达区间
47-334aa
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氨基酸序列
SDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVHEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCHPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLV
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分子量
43.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2RX7, a member of the purinergic receptor family, encodes a protein that functions as a ligand-gated ion channel, primarily activated by ATP. This receptor plays a critical role in various physiological processes, including extracellular ATP signaling, the modulation of inflammation, and the regulation of immune responses. Research has highlighted P2RX7's significance in the pathogenesis of several diseases, including neurodegenerative disorders, chronic pain, and autoimmune diseases. Abnormal activation of P2RX7 can lead to excessive inflammatory responses and cell death, indicating its potential as a therapeutic target. The development of P2RX7 recombinant proteins allows for in-depth studies into its structure-function relationships, signaling pathways, and interaction with other cellular components. These studies are vital for understanding how P2RX7 contributes to disease mechanisms and for exploring novel treatment strategies that could modulate its activity. Through recombinant protein technology, researchers can generate purified and functional P2RX7 for biochemical assays, pharmacological studies, and potential therapeutic applications, making it a focal point of ongoing biomedical research.
