Analytical Data
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基因名
GPR161
- Application
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别名
GPR161；G-Protein coupled receptor 161
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N6U8
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表达区间
1-28aa
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氨基酸序列
MSLNSSLSCRKELSNLTEEEGGEGGVII
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分子量
30.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR161 is a member of the G protein-coupled receptor (GPCR) family, playing a significant role in various physiological processes and signaling pathways. It is particularly known for its involvement in the Hedgehog (Hh) signaling pathway, which is crucial for embryonic development and tissue homeostasis. Dysregulation of this pathway, often due to GPR161 dysfunction, has been implicated in several malignancies and developmental disorders. The study of GPR161 and its recombinant protein offers insights into its structural and functional properties, facilitating a better understanding of its role in cellular signaling. By investigating the mechanisms of GPR161, researchers aim to uncover its potential as a therapeutic target for conditions associated with aberrant Hh signaling. The generation of recombinant GPR161 protein allows for more detailed biochemical and pharmacological analyses, such as ligand-binding studies and receptor activation assays, enabling the elucidation of its downstream effects and interactions with other cellular components. This research enhances the overall understanding of GPCR biology and paves the way for novel treatment strategies targeting GPR161-related pathways in disease.
