Analytical Data
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Gene name
CTTN
- Application
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Alternative Names
CTTN；EMS1；Src substrate cortactin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14247
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Expression Region
1-513aa
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AA Sequence
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQ EHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAV GHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHAS QKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYG IDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGW DHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKT VPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEA RRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPV SGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYD EYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGR YGLFPANYVELRQ
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Molecular Weight
84 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CTTN (Cortactin) is an actin-bindin g protein that plays a crucial role in actin cytoskeleton dynamics, cell migration, and adhesion. It has been implicated in various cellular processes, including endocytosis, cell signaling, and the formation of membrane protrusions. Research has shown that abnormal expression and activity of CTTN are associated with several diseases, particularly cancer, where it contributes to increased cell motility and invasion. Given its significant role in cancer progression, CTTN has emerged as a potential therapeutic target. Understanding the structure and function of CTTN is vital for developing effective strategies to modulate its activity in pathological conditions. The recombinant production of CTTN provides a valuable tool for studying its biochemical properties, interaction with other proteins, and its role in cellular processes. This research not only enhances our understanding of CTTN’s contribution to cellular mechanics but also aids in the identification of novel drug targets and therapeutic approaches in cancer treatment. Overall, the study of CTTN recombinant proteins is essential for deciphering the complex mechanisms governing cell behavior and developing innovative strategies to counteract diseases associated with its dysregulation.
