Analytical Data
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Gene name
PAX6
- Application
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Alternative Names
PAX6；AN2；Paired box Protein Pax-6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P26367
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Expression Region
2-422aa
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AA Sequence
29aa_Tag_QNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDI SRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKR ECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGM YDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISS NGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARER LAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFS TSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLP MQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTT STGLISPGVSVPVQVPGSEPDMSQYWPRLQLEESGGGGSPGRRRRRRRRR RR
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PAX6 is a pivotal transcription factor that plays a crucial role in eye development, neurogenesis, and organogenesis. Mutations in the PAX6 gene are associated with a variety of congenital eye disorders, such as aniridia and Peters anomaly, highlighting its importance in ocular biology. The study of PAX6 recombinant proteins focuses on understanding the molecular mechanisms underlying its function and regulation. By producing and analyzing PAX6 recombinant proteins, researchers can investigate the interactions of PAX6 with other cellular factors, its role in gene expression regulation, and its regulatory pathways during developmental processes. Furthermore, these studies can help elucidate the effects of specific mutations and could pave the way for potential therapeutic interventions in PAX6-related diseases. The development of PAX6 recombinant proteins also facilitates the exploration of its potential in regenerative medicine and tissue engineering, as understanding its signaling pathways may unlock new strategies for repairing or regenerating affected ocular tissues. Overall, the recombinant protein approach provides valuable insights into the functional complexities of PAX6, advancing our knowledge of developmental biology and its clinical implications.
