Analytical Data
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基因名
CXCL13
- Application
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别名
CXCL13；BCA1；BLC；SCYB13;C-X-C motif chemokine 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q53X90
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表达区间
23-109aa
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氨基酸序列
VLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNK SIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP
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分子量
10 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCL13, a chemokine belonging to the CXC family, plays a crucial role in B cell development and localization within secondary lymphoid organs. It is primarily produced by follicular dendritic cells and is essential for the formation and maintenance of B cell follicles and germinal centers. Research has indicated that CXCL13 is not only pivotal in normal immune responses but also implicated in various pathological conditions such as autoimmune diseases, lymphomas, and chronic infections. The ability of CXCL13 to attract B cells and its involvement in the formation of ectopic lymphoid structures highlight its potential as a therapeutic target. Recent studies have moved towards the development of recombinant CXCL13 proteins to further explore its functions and mechanisms in both healthy and diseased states. These recombinant proteins can be used in various experimental setups, including in vivo models, to investigate their roles in immune responses, B cell trafficking, and tissue organization. The study of CXCL13 and its recombinant forms may yield insights into targeted therapies for immune-related disorders, making it a significant focus within immunology and therapeutic development.
