Analytical Data
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Gene name
CXCL1
- Application
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Alternative Names
CXCL1；GRO；GRO1；GROA;Growth-regulated alpha Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09341
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Expression Region
35-107aa
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AA Sequence
ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKA CLNPASPIVKKIIEKMLNSDKSN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCL1, also known as growth-regulated oncogene-alpha (GRO-α), is a chemokine that plays a vital role in the immune response, inflammation, and cellular migration. It is primarily produced by various cell types, including macrophages, neutrophils, and endothelial cells, in response to pro-inflammatory stimuli. The CXCL1 protein is particularly important for recruiting neutrophils to sites of tissue injury or infection, making it a crucial player in the body's defense mechanisms. Elevated levels of CXCL1 have been associated with various pathological conditions, including cancer, chronic inflammatory diseases, and autoimmune disorders. Given its significant role in these processes, CXCL1 has garnered interest as a potential therapeutic target and biomarker for disease progression. The production of recombinant CXCL1 protein facilitates detailed studies of its functional properties, receptor interactions, and signaling pathways, which are vital for understanding its role in health and disease. Additionally, recombinant CXCL1 can be utilized in drug development and therapeutic interventions aimed at modulating the immune response. Overall, ongoing research into recombinant CXCL1 protein aims to uncover its complex biology and therapeutic potential, further elucidating its implications in physiology and pathology.
