Analytical Data
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Gene name
DAXX
- Application
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Alternative Names
DAXX；BING2；DAP6；Death domain-associated Protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UER7
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Expression Region
1-740aa
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AA Sequence
MATANSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGS SSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFL ASAEFCNILSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAAT TSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSRRQIQRLEQLLALYVA EIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTG RVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARH SLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDP ALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQG TSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEE EEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSL QISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE QPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTV LENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVE RQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCI PSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
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Molecular Weight
108 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DAXX (Death-domain associated protein) is a multifunctional protein known for its roles in various cellular processes, including apoptosis, gene regulation, and chromatin remodeling. It was initially identified as a protein that interacts with the death domain of Fas, a crucial receptor in the apoptotic pathway. Over time, research has revealed that DAXX also participates in the regulation of cellular stress responses, transcriptional regulation, and the maintenance of genome stability. There is a growing body of evidence suggesting that DAXX plays a significant role in the development and progression of various cancers, as it can influence tumor suppressor pathways and oncogenic signaling. Moreover, mutations and altered expression levels of DAXX have been linked to specific malignancies, highlighting its potential as a biomarker for cancer prognosis and therapy response. Additionally, DAXX's involvement in the DNA damage response and its interactions with other key regulatory proteins underscore its importance in maintaining cellular health. As researchers continue to explore the complexities of DAXX's functions, it is becoming increasingly clear that understanding this protein could lead to novel therapeutic strategies targeting cancer and other diseases associated with its dysregulation. This multifaceted role makes DAXX a critical subject of study in molecular biology and cancer research, paving the way for future discoveries that may improve clinical outcomes in cancer treatment.
