Analytical Data
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基因名
DAXX
- Application
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别名
DAXX；BING2；DAP6；Death domain-associated Protein 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UER7
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表达区间
1-740aa
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氨基酸序列
MATANSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGS SSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFL ASAEFCNILSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAAT TSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSRRQIQRLEQLLALYVA EIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTG RVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARH SLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDP ALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQG TSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEE EEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSL QISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE QPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTV LENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVE RQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCI PSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
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分子量
108 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAXX (Death-domain associated protein) is a multifunctional protein known for its roles in various cellular processes, including apoptosis, gene regulation, and chromatin remodeling. It was initially identified as a protein that interacts with the death domain of Fas, a crucial receptor in the apoptotic pathway. Over time, research has revealed that DAXX also participates in the regulation of cellular stress responses, transcriptional regulation, and the maintenance of genome stability. There is a growing body of evidence suggesting that DAXX plays a significant role in the development and progression of various cancers, as it can influence tumor suppressor pathways and oncogenic signaling. Moreover, mutations and altered expression levels of DAXX have been linked to specific malignancies, highlighting its potential as a biomarker for cancer prognosis and therapy response. Additionally, DAXX's involvement in the DNA damage response and its interactions with other key regulatory proteins underscore its importance in maintaining cellular health. As researchers continue to explore the complexities of DAXX's functions, it is becoming increasingly clear that understanding this protein could lead to novel therapeutic strategies targeting cancer and other diseases associated with its dysregulation. This multifaceted role makes DAXX a critical subject of study in molecular biology and cancer research, paving the way for future discoveries that may improve clinical outcomes in cancer treatment.
