Analytical Data
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Gene name
CSNK1A1
- Application
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Alternative Names
CSNK1A1;Casein kinase I isoform alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48729
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Expression Region
2-337aa
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AA Sequence
ASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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Molecular Weight
42.8kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1A1, or Casein Kinase 1 Alpha 1, is a serine/threonine protein kinase that plays a critical role in various cellular processes, including cell cycle regulation, circadian rhythms, and Wnt signaling pathways. This enzyme is part of the casein kinase 1 (CK1) family, which is known for its involvement in the phosphorylation of diverse substrates, influencing their activity and stability. Dysregulation of CSNK1A1 has been implicated in several diseases, including certain types of cancer, neurodegenerative diseases, and metabolic disorders, making it an attractive target for therapeutic intervention. The study of CSNK1A1, particularly through the production of recombinant protein, allows researchers to explore its biochemical properties, substrate interactions, and the mechanisms by which it contributes to cellular signaling. Recombinant CSNK1A1 can be utilized in various experimental settings to elucidate its role in disease pathology, screen for small molecule inhibitors, and assess potential biomarkers for conditions associated with CK1 dysregulation. Understanding the structure and function of this kinase is essential for developing targeted therapies and advancing our knowledge of its biological significance. Through recombinant protein studies, we can gain insights into the specific molecular pathways associated with CSNK1A1, paving the way for innovative approaches in drug discovery and the treatment of related diseases.
