Analytical Data
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Gene name
Cmklr2
- Application
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Alternative Names
(Chemerin chemokine-like receptor 2)(Chemokine-like receptor 2)(G-protein coupled receptor 1)
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Species
Rat
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P46090
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Expression Region
1-353aa
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Molecular Weight
42.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The Cmklr2 protein, a member of the chemokine receptor family, plays a crucial role in the immune system by mediating various cellular responses to chemokines, which are signaling molecules involved in cell migration and immune surveillance. Understanding the structure and function of Cmklr2 is essential due to its involvement in numerous physiological processes, including inflammation, immune cell trafficking, and tissue homeostasis. Recent studies have unveiled Cmklr2's significant role in the pathophysiology of several diseases, such as autoimmune disorders and cancer, highlighting its potential as a therapeutic target. Researchers are particularly interested in the signaling pathways activated by Cmklr2, as well as how its interaction with different ligands can influence immune responses. The development of recombinant Cmklr2 proteins has facilitated the exploration of its biological functions and the mechanisms underlying its effects in various cellular contexts. By employing advanced techniques such as X-ray crystallography and functional assays, studies aimed at elucidating the receptor's structure-function relationship are paving the way for novel treatment strategies targeting Cmklr2-related pathways. Ultimately, understanding Cmklr2 and its potential as a biomarker or therapeutic target could lead to innovative interventions in various diseases where the immune system plays a critical role.
