Analytical Data
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Gene name
CCR1
- Application
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Alternative Names
CCR1；CMKBR1；CMKR1；SCYAR1；C-C chemokine receptor type 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32246
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Expression Region
1-355aa
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AA Sequence
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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Molecular Weight
42.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR1 (C-C chemokine receptor type 1) is a member of the chemokine receptor family, primarily involved in the immune system's response to inflammation and infection. It plays a crucial role in the recruitment of immune cells, such as monocytes and T lymphocytes, to sites of injury or infection, thereby mediating various physiological and pathological processes. The study of CCR1 has gained significant attention due to its association with several diseases, including autoimmune disorders, viral infections, and cancer. Researchers have focused on understanding the receptor's structure, function, and signaling pathways to develop therapeutic strategies targeting CCR1. In particular, recombinant protein technologies have enabled the production of CCR1 for various applications, including the development of monoclonal antibodies and small-molecule inhibitors. By elucidating the receptor's role in immune responses and its potential as a therapeutic target, CCR1 research holds promise for advancing treatments in inflammatory diseases and improving patient outcomes.
