Analytical Data
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基因名
CHRM5
- Application
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08912
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表达区间
215-443aa
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分子量
31.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHRM5, or Cholinergic Receptor Muscarinic 5, is a member of the muscarinic acetylcholine receptor family, which are G protein-coupled receptors critically involved in various physiological processes, including neurotransmission, memory, and cognition. Research has indicated that CHRM5 plays a significant role in the central nervous system and is implicated in neurodegenerative diseases such as Alzheimer’s disease and schizophrenia, where its dysregulation may contribute to cognitive deficits and altered mood states. Given its potential as a therapeutic target, the expression and characterization of recombinant CHRM5 protein are essential for understanding its structure-function relationship and pharmacological properties. By utilizing recombinant DNA technology, researchers can produce CHRM5 in suitable expression systems, enabling comprehensive studies of its interaction with ligands and signaling pathways. Furthermore, the availability of purified CHRM5 protein is crucial for the development of novel drugs aimed at modulating its activity, which might lead to new treatment strategies for cognitive impairments associated with various neurological disorders. Overall, the study of CHRM5 recombinant protein not only enhances the understanding of cholinergic signaling but also holds promise for advancing therapeutic approaches in neuropharmacology.
