Analytical Data
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基因名
PLP1
- Application
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别名
PLP1；PLP；Myelin proteolipid Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P60201
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表达区间
2-277aa
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氨基酸序列
GLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYF SKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIF GDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDK FVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLC ADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATL VSLLTFMIAATYNFAVLKLMGRGTKF
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLP1 (Proteolipid Protein 1) is a crucial myelin-related protein predominantly expressed in oligodendrocytes, the myelinating cells of the central nervous system (CNS). Mutations or dysregulation of PLP1 are implicated in several demyelinating diseases, including Pelizaeus-Merzbacher disease, a severe neurodegenerative disorder characterized by hypomyelination. Given the importance of PLP1 in myelin formation and maintenance, its study has garnered considerable interest in the fields of neurobiology and regenerative medicine. Researchers utilize recombinant PLP1 proteins to investigate its structure-function relationships, post-translational modifications, and interactions with other myelin components. By using techniques such as protein expression in heterologous systems, purification, and functional assays, scientists aim to elucidate PLP1's role in myelination and its potential therapeutic implications for demyelinating conditions. Overall, understanding the intricacies of PLP1 biology not only enhances our comprehension of myelin pathophysiology but also guides the development of innovative strategies for repairing damaged CNS myelin.
