Cat: PA1000-656DB

Recombinant Human CMPK1 Protein,His

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Analytical Data

  • 基因名

    CMPK1

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CMPK1;CMK;CMPK;UCK;UMP-CMP kinase

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P30085

  • 表达区间

    1-228aa

  • 氨基酸序列

    MGSSHHHHHH SSGLVPRGSH MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG

  • 分子量

    28 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CMPK1 (cytidine monophosphate kinase 1) is an essential enzyme in nucleotide metabolism, playing a critical role in the phosphorylation of nucleoside monophosphates, particularly cytidine monophosphate (CMP), into nucleoside diphosphates. This function is vital for DNA and RNA synthesis, cellular energy homeostasis, and regulating various metabolic pathways. Aberrations in CMPK1 activity have been linked to several pathological conditions, including cancer, viral infections, and neurodegenerative diseases. Given its importance, CMPK1 has garnered attention as a potential target for therapeutic intervention. Recent studies have focused on the recombinant expression of CMPK1 to better understand its structure-function relationships, enzymatic mechanisms, and regulatory properties. Utilizing recombinant CMPK1 enables researchers to investigate its kinetic parameters, substrate specificity, and interactions with various ligands, providing insights into its role in cellular metabolism and disease. Moreover, recombinant CMPK1 can serve as a valuable tool in drug discovery and development, facilitating the screening of small molecule inhibitors or activators that could modulate its activity for therapeutic benefit. Understanding the biochemical characteristics of CMPK1 through recombinant protein studies is crucial for developing strategies to manipulate its function in disease contexts, highlighting its potential as a novel drug target.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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