Analytical Data
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Gene name
CHCHD4
- Application
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Alternative Names
Coiled-coil-helix-coiled-coil-helix domain-containing protein 4
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N4Q1
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Expression Region
1-142aa
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Molecular Weight
32 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHCHD4, a member of the conserved mitochondrial protein family, has gained considerable attention in recent years due to its critical role in mitochondrial function and cellular metabolism. This protein is known to be involved in the regulation of oxidative phosphorylation and mitochondrial dynamics, influencing energy production in cells. Disruptions in CHCHD4 function have been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its potential as a therapeutic target. Researchers are increasingly focused on the recombinant expression of CHCHD4 to study its biochemical properties, interaction with other mitochondrial proteins, and its influence on cellular stress responses. The production of recombinant CHCHD4 allows for detailed structural and functional analyses, paving the way for understanding the mechanisms underlying its role in mitochondria. As studies progress, insights into CHCHD4 may reveal novel approaches for treating mitochondrial dysfunction-related diseases, making it a promising candidate for further exploration in both basic and applied research contexts. The ongoing investigation into CHCHD4's functionalities and implications in health and disease is essential for the development of targeted therapies, thus emphasizing the relevance of recombinant protein technology in advancing our knowledge of mitochondrial biology.
