Analytical Data
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基因名
DSG3
- Application
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别名
DSG3；CDHF6；Desmoglein-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32926
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表达区间
50-615aa
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氨基酸序列
EWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGR
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分子量
65.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DSG3, or desmoglein 3, is a member of the desmosomal cadherin family, primarily expressed in epithelial tissues, particularly in the skin and mucous membranes. It plays a crucial role in the formation and maintenance of desmosomes, cell structures that provide strong adhesion between adjacent cells, thus contributing to tissue integrity and function. Dysregulation or autoantibody formation against DSG3 has been implicated in autoimmune blistering diseases, notably pemphigus vulgaris, where the immune system attacks these desmosomal proteins, leading to severe skin and mucosal lesions. Research on recombinant DSG3 has gained prominence as it offers potential insights into the pathogenesis of pemphigus vulgaris, allowing for the exploration of targeted therapies and diagnostic tools. Additionally, studying the structure and function of DSG3 at the molecular level can aid in understanding its interactions with other cellular components and its role in cell signaling pathways. The development of recombinant DSG3 proteins provides valuable resources for producing monoclonal antibodies and for conducting functional studies, which could pave the way for novel therapeutic strategies to modulate immune responses in affected individuals. Understanding the immune response to DSG3, in both healthy and diseased states, can ultimately lead to improved disease management and treatment options for patients suffering from pemphigus and related disorders.
