Analytical Data
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Gene name
KLHL36
- Application
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Alternative Names
KLHL36; C16orf44Kelch-like protein 36
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N4N3
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Expression Region
1-553aa
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Molecular Weight
78.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KLHL36, a member of the kelch-like protein family, has garnered attention in recent years due to its potential role in various cellular processes and disease mechanisms. This protein contains multiple kelch repeat domains, which are known to facilitate protein-protein interactions and are implicated in the regulation of diverse biological pathways, including cytoskeletal dynamics, signal transduction, and cellular stress responses. Research indicates that KLHL36 may play a role in the ubiquitin-proteasome system, acting as a substrate adaptor for cullin-RING ligases, which are essential for targeted protein degradation. Dysregulation of KLHL36 has been associated with several pathologies, including cancer and neurodegenerative disorders, suggesting its involvement in maintaining cellular homeostasis and response to stress. Moreover, studies have revealed that KLHL36 interacts with key signaling molecules, potentially influencing pathways related to cell proliferation and apoptosis. Given its multifunctional roles and potential as a therapeutic target, the recombinant production of KLHL36 is valuable for elucidating its structure-function relationship and for further studies aiming to understand its biological significance in health and disease. Such insights may pave the way for novel interventions in diseases where KLHL36 is implicated, underscoring the importance of continued research in this area.
